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Alnylam Pharmaceuticals

ALNY
59
Biotechnology · Healthcare
Also trades as: 0HD2.L
Exchange
NASDAQ
Winston Score
59
Winston is curious
A decent business — some strong pillars, some weaker.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Exceptional
Growth
Good
Cash Flow
Good
Stability
Good
Valuation
Good

Winston Score History

The full picture

Alnylam Pharmaceuticals is a biotech company that makes medicines using a technology called RNA interference, or RNAi. This technology works by silencing specific genes in the body that cause disease. Alnylam focuses on rare and serious conditions, including a nerve disease called hereditary transthyretin amyloidosis (hATTR) and high triglycerides, selling drugs like Onpattro, Amvuttra, and Leqvio to patients and healthcare systems worldwide.

The company earns money primarily through drug sales and also through royalties and partnerships with larger pharmaceutical companies like Novartis. Alnylam operates mainly in the US and Europe, with a growing global footprint, and its core competitive advantage is its pioneering position in RNAi — a platform that took decades and billions of dollars to develop, making it hard for rivals to replicate quickly. The key growth driver is expanding its approved drug portfolio and pipeline into more common diseases like cardiovascular conditions, though the main risk is the high cost of developing new drugs and potential competition from other gene-silencing technologies.

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Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+66.9% YoY

YoY Growth Rate

Revenue accelerating

EPS Growth

+341.2% YoY

YoY Growth Rate

EPS growth accelerating

Insider Activity

0.4%ownership

Flat

Insider ownership roughly steady over the past year

Cash Position

Cash flow positive

$3.3B cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Company generates more cash than it spends — no dilution risk from fundraising

Revenue accelerating

Alnylam Pharmaceuticals grew revenue 67% year-over-year and the growth rate is speeding up. That's the kind of momentum growth investors look for — the question is whether margins can follow.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
76.9%
Premium pricing power — 76.9% gross margin
Profit after running costs
Operating Margin
17.9%
Healthy — 17.9% operating margin
Return on the money invested
ROCE
38.1%
Exceptional — 38.1% return on capital

ROIC above 25%. Every dollar invested in the business earns more than 25 cents back per year.

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Growth

Sales growth
Sales YoY
+95.1%
Fast-growing sales (+95.1% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
6/8 quarters
Earnings grew in most of the last 8 quarters

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Cash Flow

Profit that turns into cash
Cash Conversion
79%
Modest — 79% of profit becomes cash
Spare cash per sale
FCF Margin
11.3%
Modest free cash flow (11.3%)

FCF margin between 10% and 20%. Every $100 in sales becomes $10 to $20 in real cash.

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Stability

What it owes vs what it owns
Debt / Equity
0.94
Moderate — manageable debt (0.94)
Covers its interest
Interest Cover
3.08x
Tight — interest eats into profit (3.1x)

Interest coverage between 3 and 8. Profits cover interest several times over.

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Valuation

Price vs profit
P/E Ratio (TTM)
38.7x
no trend
Pricey — P/E 38.7

P/E over 35. The market is pricing in heavy, sustained growth.

Cheaper or dearer next year
P/E vs Forward
+22.7
GROWING
Earnings expected to grow meaningfully — cheaper on forward P/E (38.7 → 16.0)

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Dividends

Not applicable for this business.
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