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Alnylam Pharmaceuticals

DUL.DE
59
Biotechnology · Healthcare
Exchange
Frankfurt Stock Exchange
Winston Score
59
Winston is curious
A decent business — some strong pillars, some weaker.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Strong
Growth
Good
Cash Flow
Strong
Stability
Mixed
Valuation
Good

Winston Score History

The full picture

Alnylam Pharmaceuticals is a biotech company that makes medicines for rare, serious diseases caused by faulty genes. Its drugs work by "silencing" specific genes that cause illness — a technology called RNA interference, or RNAi. Its main approved products include Onpattro, Givlaari, Oxlumo, and Leqvio, which treat conditions like a nerve disease called hATTR amyloidosis and a liver disorder called acute hepatic porphyria.

The company earns money by selling these specialty drugs directly and through partnerships with larger pharmaceutical companies, including Novartis, which helps commercialize Leqvio globally. Alnylam operates mainly in the United States and Europe and generates roughly $2–3 billion in annual revenue. Its core advantage is its pioneering position in RNAi technology, which took decades to develop and is difficult for competitors to replicate quickly. The key growth driver is expanding its pipeline of RNAi medicines into more common diseases, though the main risk is the high cost and uncertainty of drug development and regulatory approval.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+67.9% YoY

YoY Growth Rate

Revenue accelerating

EPS Growth

+346.0% YoY

YoY Growth Rate

EPS growth accelerating

Insider Activity

0.4%ownership

Flat

Insider ownership roughly steady over the past year

Cash Position

Cash flow positive

€3.3B cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Company generates more cash than it spends — no dilution risk from fundraising

Revenue accelerating

Alnylam Pharmaceuticals grew revenue 68% year-over-year and the growth rate is speeding up. That's the kind of momentum growth investors look for — the question is whether margins can follow.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
76.9%
Premium pricing power — 76.9% gross margin
Profit after running costs
Operating Margin
17.9%
Healthy — 17.9% operating margin
Return on the money invested
ROCE
24.2%
Exceptional — 24.2% return on capital

ROIC between 15% and 25%. Every dollar invested in the business earns 15 to 25 cents back per year.

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Growth

Sales growth
Sales YoY
+95.4%
Fast-growing sales (+95.4% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
6/8 quarters
Earnings grew in most of the last 8 quarters

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Cash Flow

Profit that turns into cash
Cash Conversion
110%
Turns 110% of profit into real cash
Spare cash per sale
FCF Margin
16.5%
Converts sales into free cash efficiently (16.5%)

FCF margin between 10% and 20%. Every $100 in sales becomes $10 to $20 in real cash.

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Stability

What it owes vs what it owns
Debt / Equity
2.05
Heavy debt load (2.05)
Covers its interest
Interest Cover
3.07x
Tight — interest eats into profit (3.1x)

Interest coverage between 3 and 8. Profits cover interest several times over.

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Valuation

Price vs profit
P/E Ratio (TTM)
33.2x
no trend
Pricey — P/E 33.2

P/E above the market average. People are paying up for expected growth.

Cheaper or dearer next year
P/E vs Forward
+15.4
GROWING
Earnings expected to grow meaningfully — cheaper on forward P/E (33.2 → 17.7)

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Dividends

Not applicable for this business.
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