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Alterity Therapeutics Limited

ATH.AX
25
Biotechnology · Healthcare
Price
A$0.49
-0.01 (-2.00%)
Market Cap
A$106.6M
Exchange
Australian Securities Exchange
Winston Score
25
Winston is worried
Below-average fundamentals — multiple weak pillars.
Based on the IPO prospectus (annual filing). This score will refine automatically once the company reports its first quarters.
Data as of Aug 23, 2026 · filings through Dec 31, 2025
How the score breaks down
Quality
Mixed
Growth
Mixed
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+277.0% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 33.9M (2021) → 127.9M (2025)

Winston Score History

The full picture

Alterity Therapeutics is a small Australian biotechnology company focused on developing drugs to treat rare and serious brain diseases. Its main work centers on a drug candidate called ATH434, which is designed to slow the progression of multiple system atrophy, a rare and currently incurable neurological disorder. The company does not yet sell any commercial products and operates entirely in the research and clinical trial stage.

Alterity earns no meaningful revenue from product sales and is funded primarily through capital raises from investors. It is headquartered in Melbourne, Australia, but conducts clinical trials across multiple countries including the United States. Like most early-stage biotech companies, it spends far more money than it brings in, which explains the deeply negative operating margin. The key risk is that ATH434 must successfully pass clinical trials and gain regulatory approval before the company can generate real revenue — a process that is expensive, uncertain, and can take many years.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-100.0% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+32.9% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

A$14M/ year

Declining (-23% vs prior year)

264.8% of revenue

14.7x the sector average (18%)

R&D spend declining — could signal cost-cutting or efficiency

Insider Activity

35.3%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~7 months

A$49M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Short runway — potential dilution ahead through share issuance

Cash watch

Alterity Therapeutics Limited has less than a year of cash at its current burn rate. Growth investors should watch for potential share dilution from future fundraising — that directly reduces your ownership.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
97.7%
Premium pricing power — 97.7% gross margin
Profit after running costs
Operating Margin
-268.0%
Losing money on operations — -268.0%
Return on the money invested
ROCE
-34.3%
Weak — -34.3% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+35.3%
Fast-growing sales (+35.3% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
N/A
Data not available

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-210.5%
Burning cash (-210.5%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.00
Conservative — low debt load (0.00)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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