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BioCryst Pharmaceuticals

BCRX
60
Biotechnology · Healthcare
Price
$9.55
-0.11 (-1.14%)
Market Cap
$2.43B
Exchange
NASDAQ
Winston Score
60
Winston is curious
A decent business — some strong pillars, some weaker.
Based on the IPO prospectus (annual filing). This score will refine automatically once the company reports its first quarters.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Exceptional
Growth
Mixed
Cash Flow
Exceptional
Stability
Mixed
Valuation
Data not available

Share count rising — dilution

+22.0% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 179.1M (2021) → 218.6M (2025)

Winston Score History

The full picture

BioCryst Pharmaceuticals is a biotechnology company that makes medicines for rare diseases — conditions that affect very few people but can be serious or life-threatening. Its main product is Orladeyo (berotralstat), a once-daily pill that helps prevent attacks in people with hereditary angioedema (HAE), a rare genetic disorder that causes painful swelling episodes. BioCryst sells primarily to patients and specialty pharmacies in the United States and Europe.

The company earns revenue by selling Orladeyo directly to patients through specialty distribution channels, with most sales coming from the US market. BioCryst is a relatively small biotech with a market cap around $2.3 billion, and its competitive edge comes from Orladeyo being one of the few oral preventive treatments for HAE in a market with limited competition. However, the company is still unprofitable, spending heavily on research and sales efforts, and its key risk is whether Orladeyo revenue can grow fast enough to cover those ongoing losses before additional capital is needed.

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Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+33.6% YoY

YoY Growth Rate

Strong revenue growth

EPS Growth

>+1,000% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$166M/ year

Flat (-5% vs prior year)

19.0% of revenue

In line with sector average (18%)

Steady R&D investment year-over-year

Insider Activity

15.4%ownership

Rising

Insiders increasing their stake — aligned with shareholders

Cash Position

Cash flow positive

$353M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Company generates more cash than it spends — no dilution risk from fundraising

Strong grower

BioCryst Pharmaceuticals is growing revenue at 34% year-over-year. The Winston Score penalises unprofitable companies, but revenue at this pace tells a different story — this is a company still in "build mode."

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
97.8%
Premium pricing power — 97.8% gross margin
Profit after running costs
Operating Margin
39.0%
Excellent — 39.0% operating margin
Return on the money invested
ROCE
110.7%
Exceptional — 110.7% return on capital

ROIC above 25%. Every dollar invested in the business earns more than 25 cents back per year.

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Growth

Sales growth
Sales YoY
+94.1%
Fast-growing sales (+94.1% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
N/A
Data not available

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Cash Flow

Profit that turns into cash
Cash Conversion
125%
Turns 125% of profit into real cash
Spare cash per sale
FCF Margin
37.4%
Converts sales into free cash efficiently (37.4%)

Free cash flow margin above 20%. Out of every $100 in sales, more than $20 is real cash they keep.

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Stability

What it owes vs what it owns
Debt / Equity
N/A
Data not available
Covers its interest
Interest Cover
4.32x
Adequate interest coverage (4.3x)

Interest coverage between 3 and 8. Profits cover interest several times over.

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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