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C4 Therapeutics

CCCC
20
Biotechnology · Healthcare
Price
$4.00
-0.03 (-0.74%)
Market Cap
$442.3M
Exchange
NASDAQ
Winston Score
20
Winston is worried
Weak fundamentals across most pillars.
Based on the IPO prospectus (annual filing). This score will refine automatically once the company reports its first quarters.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+80.0% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 46.0M (2021) → 82.9M (2025)

Winston Score History

The full picture

C4 Therapeutics is a biotechnology company that develops experimental medicines designed to destroy harmful proteins inside the body. Instead of blocking a protein the way most drugs do, C4's approach — called targeted protein degradation — uses the body's own waste-disposal system to eliminate proteins that cause disease. The company focuses on cancer and other serious illnesses, and its pipeline includes drugs targeting proteins linked to blood cancers and solid tumors.

C4 makes no product revenue yet; it funds its research through partnerships and collaboration agreements with larger pharmaceutical companies, including a notable deal with Roche. The company operates primarily in the United States and is a small-cap firm still in the clinical-stage, meaning none of its drugs have been approved for sale. Its high gross margin reflects collaboration revenue rather than commercial sales, while its deeply negative operating margin shows how much it spends on research. The key risk is whether its lead drug candidates can prove safe and effective in clinical trials before the company needs to raise additional cash.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-100.0% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+51.4% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$104M/ year

Declining (-6% vs prior year)

290.0% of revenue

16.1x the sector average (18%)

R&D spend declining — could signal cost-cutting or efficiency

Insider Activity

24.3%ownership

Rising

Insiders increasing their stake — aligned with shareholders

Cash Runway

5+ years

Quarterly Free Cash Flow

↑ Burn rate improving

$254M cash & investments at current burn rate

Revenue declining

C4 Therapeutics's revenue is actually shrinking. In a growth stock, that removes the core investment thesis. The low Winston Score here may be warranted — unless there's a turnaround story.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
77.8%
Premium pricing power — 77.8% gross margin
Profit after running costs
Operating Margin
-290.7%
Losing money on operations — -290.7%
Return on the money invested
ROCE
-40.7%
Weak — -40.7% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+1.0%
Nearly flat sales (+1.0% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
N/A
Data not available

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-276.2%
Burning cash (-276.2%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.00
Conservative — low debt load (0.00)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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