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Caribou Biosciences

CRBU
27
Biotechnology · Healthcare
Exchange
NASDAQ
Winston Score
27
Winston is worried
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Mixed
Cash Flow
Weak
Stability
Data not available
Valuation
Data not available

Winston Score History

The full picture

Caribou Biosciences is a clinical-stage biotechnology company that uses gene-editing technology to develop cancer treatments. Its main focus is on "off-the-shelf" cell therapies — medicines made from donated cells that can be given to any patient, rather than having to be custom-made for each person. The company's lead programs target blood cancers like leukemia and lymphoma, and its potential customers are hospitals and cancer treatment centers.

Caribou makes no product revenue yet. It funds its research through partnerships, grants, and money raised from investors. The company is based in Berkeley, California and operates primarily in the United States, though it runs clinical trials in multiple countries. Its core competitive edge is its proprietary CRISPR genome-editing platform, which it uses to engineer more effective immune cells. The biggest risk the company faces is that its drug candidates could fail in clinical trials, which would threaten its ability to raise more money and continue operating.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-43.8% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+58.6% YoY

YoY Growth Rate

EPS growth accelerating

Insider Activity

9.7%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~15 months

$114M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Adequate runway but may need to raise capital within 2 years

Revenue declining

Caribou Biosciences's revenue is actually shrinking. In a growth stock, that removes the core investment thesis. The low Winston Score here may be warranted — unless there's a turnaround story.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-1690.4%
Losing money on operations — -1690.4%
Return on the money invested
ROCE
-111.6%
Weak — -111.6% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+10.0%
Steady sales growth (+10.0% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
5/8 quarters
Mixed — about half the quarters showed growth

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-958.5%
Burning cash (-958.5%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
N/A
Data not available
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
no trend
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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