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CytomX Therapeutics

CTMX
29
Biotechnology · Healthcare
Exchange
NASDAQ
Winston Score
29
Winston is worried
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Winston Score History

The full picture

CytomX Therapeutics is a clinical-stage biotechnology company focused on developing cancer treatments. It uses a proprietary technology called Probody therapeutics, which are engineered antibodies designed to stay inactive in healthy tissue and only activate inside tumors. This approach aims to reduce the side effects that often come with traditional cancer drugs, and CytomX partners with larger pharmaceutical companies to develop these treatments.

The company makes money primarily through licensing deals, research collaborations, and milestone payments from pharmaceutical partners rather than selling approved drugs directly. It operates mainly in the United States and is still in the early stages of clinical development, meaning it spends far more than it earns — reflected in its deeply negative operating margin. The key growth driver is advancing its pipeline candidates through clinical trials and securing additional partnerships, but the main risk is that clinical-stage biotechs frequently fail to get drugs approved, and CytomX has no guaranteed path to generating product revenue.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-92.4% YoY

YoY Growth Rate

Revenue declining

EPS Growth

<−1,000% YoY

YoY Growth Rate

Earnings declining

Insider Activity

20.5%ownership

Rising

Insiders increasing their stake — aligned with shareholders

Cash Runway

~5 years

$330M cash & investments

Quarterly Free Cash Flow

→ Burn rate stable

$330M cash & investments at current burn rate

Revenue declining

CytomX Therapeutics's revenue is actually shrinking. In a growth stock, that removes the core investment thesis. The low Winston Score here may be warranted — unless there's a turnaround story.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-1677.1%
Losing money on operations — -1677.1%
Return on the money invested
ROCE
-28.3%
Weak — -28.3% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-87.0%
Shrinking sales (-87.0% YoY)
Profit growth
EPS YoY
-178.1%
Earnings shrinking (-178.1% YoY)

Earnings per share down more than 10%. Either a bad year, or a real decline.

How steady the profit is
EPS Consistency
4/8 quarters
Earnings inconsistent quarter-to-quarter

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-452.1%
Burning cash (-452.1%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.02
Conservative — low debt load (0.02)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
no trend
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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