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Entrada Therapeutics

TRDA
23
Biotechnology · Healthcare
Price
$7.57
-0.03 (-0.39%)
Market Cap
$293.9M
Exchange
NASDAQ
Winston Score
23
Winston is worried
Weak fundamentals across most pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Data not available
Valuation
Data not available

Share count rising — dilution

+32.5% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 31.2M (2021) → 41.4M (2025)

Winston Score History

The full picture

Entrada Therapeutics is a biotechnology company focused on developing medicines for rare diseases, particularly those affecting muscles and the nervous system. Its core technology is a platform called Endosomal Escape Vehicles (EEVs), which are designed to deliver therapeutic molecules — like peptides and oligonucleotides — inside cells more effectively than older methods. The company's main target diseases include Duchenne muscular dystrophy (DMD) and other serious genetic conditions with few or no existing treatments.

Entrada does not yet sell any approved products, so it earns revenue primarily through research partnerships and licensing deals rather than product sales. It operates mainly in the United States and is a small, clinical-stage company with a market cap around $300 million. The deeply negative margins reflect heavy spending on research and clinical trials, which is typical for early-stage biotech firms. The biggest risk is clinical failure — if its drug candidates do not prove safe and effective in trials, the company has no fallback revenue stream to sustain operations.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-53.9% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+2.9% YoY

YoY Growth Rate

Slow EPS growth

R&D Spend

$142M/ year

Rising (+14% vs prior year)

559.7% of revenue

31.1x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

42.8%ownership

Declining

Insider ownership declining — could be dilution or selling

Cash Runway

~21 months

$223M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Adequate runway but may need to raise capital within 2 years

Heavy R&D investment

Entrada Therapeutics is putting 560% of revenue into R&D and that number is rising. That's 31.1x the sector average.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-5007.0%
Losing money on operations — -5007.0%
Return on the money invested
ROCE
-75.6%
Weak — -75.6% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-94.1%
Shrinking sales (-94.1% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
2/8 quarters
Earnings rarely grow — volatile business

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-2883.2%
Burning cash (-2883.2%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
N/A
Data not available
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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