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Exelixis

EXEL
83
Biotechnology · Healthcare
Also trades as: 0IJO.L
Price
$54.08
+0.39 (+0.73%)
Market Cap
$13.59B
Exchange
NASDAQ
Winston Score
83
Winston is happy
A high-quality business with solid fundamentals.
Data as of Aug 23, 2026 · filings through Jul 3, 2026
How the score breaks down
Quality
Exceptional
Growth
Exceptional
Cash Flow
Exceptional
Stability
Good
Valuation
Strong

Share count falling — buybacks

12.6% over 5y

The company has reduced its share count over this period, returning value to shareholders through buybacks.

Diluted shares outstanding: 322.4M (2021) → 281.9M (2026)

Winston Score History

The full picture

Exelixis is a biotechnology company that discovers and develops cancer-fighting drugs. Its main product is cabozantinib, sold under the brand names Cabometyx and Cometriq, which is used to treat kidney cancer, liver cancer, and thyroid cancer. Doctors and hospitals across the U.S. and internationally prescribe these medicines to patients with hard-to-treat tumors.

Exelixis makes money primarily by selling cabozantinib directly and by collecting royalties from its partner Roche, which sells the drug in markets outside the U.S. The company operates mainly in the United States and generates roughly $2 billion in annual revenue, with an unusually high gross margin above 96% because drug sales carry very low production costs once approved. Its biggest risk is heavy dependence on a single drug family — if a competitor develops a better treatment or cabozantinib loses market share, revenue could fall sharply, making pipeline diversification the key factor to watch.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

YoY Growth Rate

Revenue data limited

EPS Growth

YoY Growth Rate

EPS data limited

R&D Spend

$825M/ year

Declining (-9% vs prior year)

35.6% of revenue

2.0x the sector average (18%)

R&D spend declining — could signal cost-cutting or efficiency

Insider Activity

18.7%ownership

Flat

Insider ownership roughly steady over the past year

Cash Position

Cash flow positive

$1.7B cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Company generates more cash than it spends — no dilution risk from fundraising

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
96.7%
Premium pricing power — 96.7% gross margin
Profit after running costs
Operating Margin
39.5%
Excellent — 39.5% operating margin
Return on the money invested
ROCE
52.7%
Exceptional — 52.7% return on capital

ROIC above 25%. Every dollar invested in the business earns more than 25 cents back per year.

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Growth

Sales growth
Sales YoY
+9.2%
Steady sales growth (+9.2% YoY)
Profit growth
EPS YoY
+53.7%
Earnings growing fast (+53.7% YoY)

Earnings growing 25%+ a year. The compounder zone.

How steady the profit is
EPS Consistency
7/8 quarters
Every recent quarter grew earnings vs last year

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Cash Flow

Profit that turns into cash
Cash Conversion
167%
Turns 167% of profit into real cash
Spare cash per sale
FCF Margin
58.7%
Converts sales into free cash efficiently (58.7%)

Free cash flow margin above 20%. Out of every $100 in sales, more than $20 is real cash they keep.

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Stability

What it owes vs what it owns
Debt / Equity
N/A
Data not available
Covers its interest
Interest Cover
100.00x
Comfortably covers interest (100.0x)

Interest coverage above 8. Profits cover interest many times over.

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Valuation

Price vs profit
P/E Ratio (TTM)
16.4x
Fair value — P/E 16.4

P/E in the normal range. Price is roughly $15 for every $1 of yearly profit.

Cheaper or dearer next year
P/E vs Forward
+4.5
GROWING
Earnings expected to grow meaningfully — cheaper on forward P/E (16.4 → 11.9)

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Dividends

Not applicable for this business.
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