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Lexicon Pharmaceuticals

LXRX
31
Biotechnology · Healthcare
Exchange
NASDAQ
Winston Score
31
Winston is serious
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Mixed
Cash Flow
Weak
Stability
Data not available
Valuation
Data not available

Winston Score History

The full picture

Lexicon Pharmaceuticals is a drug development company that discovers and sells medicines for serious diseases. Its main approved product is Xermelo (telotristat ethyl), used to treat a rare condition called carcinoid syndrome, and it has also developed sotagliflozin, a drug targeting heart failure and diabetes. The company sells primarily to hospitals, specialty pharmacies, and patients in the United States, working within the competitive prescription drug market.

Lexicon makes money by selling its approved medicines and through licensing deals and partnerships with larger pharmaceutical companies. It operates mainly in the US and is a relatively small biotech with around a $1 billion market value. The very high gross margin reflects the typical drug business model, but the negative operating margin shows the company is still spending heavily on research and development. The biggest risk Lexicon faces is its dependence on a small number of products — if clinical trials fail or sales disappoint, the company has limited revenue to fall back on.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-97.6% YoY

YoY Growth Rate

Revenue declining

EPS Growth

-877.8% YoY

YoY Growth Rate

Earnings declining

Insider Activity

51.8%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~2 years

$191M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Adequate runway but may need to raise capital within 2 years

Revenue declining

Lexicon Pharmaceuticals's revenue is actually shrinking. In a growth stock, that removes the core investment thesis. The low Winston Score here may be warranted — unless there's a turnaround story.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Profit per sale
Gross Margin
94.4%
Premium pricing power — 94.4% gross margin
Profit after running costs
Operating Margin
-3835.3%
Losing money on operations — -3835.3%
Return on the money invested
ROCE
-31.2%
Weak — -31.2% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-29.0%
Shrinking sales (-29.0% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
7/8 quarters
Every recent quarter grew earnings vs last year

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-192.2%
Burning cash (-192.2%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
N/A
Data not available
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
no trend
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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