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Monte Rosa Therapeutics

GLUE
29
Biotechnology · Healthcare
Price
$14.30
-0.48 (-3.25%)
Market Cap
$1.21B
Exchange
NASDAQ
Winston Score
29
Winston is worried
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+40.8% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 46.5M (2021) → 65.5M (2025)

Winston Score History

The full picture

Monte Rosa Therapeutics is a biotechnology company that discovers and develops drugs designed to eliminate harmful proteins inside the body. Instead of blocking a protein's activity like traditional drugs do, Monte Rosa's approach uses the body's own waste-disposal system to break down and destroy disease-causing proteins entirely. This technique, called molecular glue degradation, is the basis for the company's drug pipeline, which targets cancers and other serious diseases.

Monte Rosa makes no product revenue yet — it earns money primarily through research partnerships and collaboration agreements with larger pharmaceutical companies. The company is based in Boston and operates mainly in the United States, with early-stage clinical programs still working through human trials. Its proprietary computational platform, called Quantitative Induced Proximity, is designed to identify molecular glue compounds faster than competitors, which is its main competitive edge. The biggest risk is that clinical trials could fail, and the company continues to burn significant cash while it waits for proof that its drugs work in patients.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-61.3% YoY

YoY Growth Rate

Revenue declining

EPS Growth

-186.7% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$142M/ year

Rising (+16% vs prior year)

114.4% of revenue

6.4x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

29.3%ownership

Declining

Insider ownership declining — could be dilution or selling

Cash Runway

~21 months

$621M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Adequate runway but may need to raise capital within 2 years

Heavy R&D investment

Monte Rosa Therapeutics is putting 114% of revenue into R&D and that number is rising. That's 6.4x the sector average.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-547.8%
Losing money on operations — -547.8%
Return on the money invested
ROCE
-34.6%
Weak — -34.6% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-83.9%
Shrinking sales (-83.9% YoY)
Profit growth
EPS YoY
-711.4%
Earnings shrinking (-711.4% YoY)

Earnings per share down more than 10%. Either a bad year, or a real decline.

How steady the profit is
EPS Consistency
4/8 quarters
Earnings inconsistent quarter-to-quarter

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-248.3%
Burning cash (-248.3%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.08
Conservative — low debt load (0.08)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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