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Personalis

PSNL
21
Medical - Diagnostics & Research · Healthcare
Price
$18.38
+1.50 (+8.89%)
Market Cap
$1.96B
Exchange
NASDAQ
Winston Score
21
Winston is worried
Weak fundamentals across most pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Weak
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+103.3% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 43.9M (2021) → 89.2M (2025)

Winston Score History

The full picture

Personalis is a genomics company that analyzes cancer DNA to help doctors and researchers better understand tumors. Its main product, NeXT Platform, sequences genetic material from cancer patients at very high depth, picking up tiny signals that standard tests might miss. The company primarily serves biopharmaceutical companies running clinical trials, as well as the U.S. Department of Veterans Affairs through a large precision medicine program.

Personalis makes money by charging for genomic sequencing services and data analysis, essentially acting as a lab that processes samples and delivers results. It operates mainly in the United States and is a relatively small company, with its competitive edge coming from the sensitivity and scale of its cancer sequencing technology. However, the company is spending far more than it earns — its operating margin is deeply negative — so a key risk is whether it can grow revenue fast enough to reach profitability before needing to raise additional capital.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+30.0% YoY

YoY Growth Rate

Revenue accelerating

EPS Growth

-30.4% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$50M/ year

Flat (+3% vs prior year)

72.2% of revenue

4.0x the sector average (18%)

Steady R&D investment year-over-year

Insider Activity

38.4%ownership

Declining

Insider ownership declining — could be dilution or selling

Cash Runway

~22 months

$213M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Adequate runway but may need to raise capital within 2 years

Revenue accelerating

Personalis grew revenue 30% year-over-year and the growth rate is speeding up. That's the kind of momentum growth investors look for — the question is whether margins can follow.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
21.2%
Thin — 21.2% gross margin
Profit after running costs
Operating Margin
-150.2%
Losing money on operations — -150.2%
Return on the money invested
ROCE
-48.4%
Weak — -48.4% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-13.3%
Shrinking sales (-13.3% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
4/8 quarters
Earnings inconsistent quarter-to-quarter

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-144.9%
Burning cash (-144.9%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.00
Conservative — low debt load (0.00)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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