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Prelude Therapeutics Incorporated

PRLD
41
Biotechnology · Healthcare
Price
$6.63
+0.13 (+2.00%)
Market Cap
$377.5M
Exchange
NASDAQ
Winston Score
41
Winston is serious
Mixed quality — meaningful strengths and weaknesses.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Strong
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+61.7% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 47.6M (2021) → 77.0M (2025)

Winston Score History

The full picture

Prelude Therapeutics is a small biotechnology company that discovers and develops cancer drugs. It focuses on targeted therapies — medicines designed to attack specific proteins that help cancer cells survive and grow. The company's main customers are patients with blood cancers and solid tumors, and it works primarily through clinical trials rather than selling approved products.

Prelude makes almost no revenue from product sales yet, which is typical for early-stage drug developers. Instead, it funds its research through equity raises, partnerships, and grants. The company operates mainly in the United States and has a market cap of roughly $300 million. Its pipeline centers on inhibitors targeting proteins like DCAF16 and WEE1, which are involved in cancer cell growth. The biggest risk the company faces is clinical failure — if its drug candidates do not show strong enough results in trials, the company could run out of cash before reaching the market.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

YoY Growth Rate

Revenue data limited

EPS Growth

+65.9% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$94M/ year

Declining (-20% vs prior year)

776.8% of revenue

43.2x the sector average (18%)

R&D spend declining — could signal cost-cutting or efficiency

Insider Activity

46.8%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~2 years

$152M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

$152M cash & investments at current burn rate

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-270.9%
Losing money on operations — -270.9%
Return on the money invested
ROCE
-44.5%
Weak — -44.5% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+220.3%
Fast-growing sales (+220.3% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
7/8 quarters
Every recent quarter grew earnings vs last year

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-148.3%
Burning cash (-148.3%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.13
Conservative — low debt load (0.13)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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