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Prime Medicine

PRME
33
Biotechnology · Healthcare
Exchange
NASDAQ
Winston Score
33
Winston is serious
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Good
Cash Flow
Weak
Stability
Weak
Valuation
Data not available

Winston Score History

The full picture

Prime Medicine is a biotechnology company working on a new type of gene editing called "prime editing." Think of DNA like a document with typos — prime editing is a tool designed to fix those typos with more precision than older methods like CRISPR. The company is focused on developing treatments for serious genetic diseases, including certain blood disorders, immune deficiencies, and liver conditions, with patients as the ultimate end market.

Prime Medicine makes no product revenue yet. It is a clinical-stage company funded primarily through cash reserves and partnerships, meaning it spends heavily on research while earning little in return — which explains its deeply negative margins. The company operates mainly in the United States and has a potential moat in its proprietary prime editing technology, which it licenses from foundational research out of Harvard. The key risk is that it must successfully advance its experimental therapies through clinical trials before its cash runs out, a challenge common to early-stage biotech companies.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+3.5% YoY

YoY Growth Rate

Slow revenue growth

EPS Growth

+41.0% YoY

YoY Growth Rate

EPS growth accelerating

Insider Activity

67.2%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~7 months

$95M cash & investments

Quarterly Free Cash Flow

→ Burn rate stable

Short runway — potential dilution ahead through share issuance

Cash watch

Prime Medicine has less than a year of cash at its current burn rate. Growth investors should watch for potential share dilution from future fundraising — that directly reduces your ownership.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-3750.9%
Losing money on operations — -3750.9%
Return on the money invested
ROCE
-129.0%
Weak — -129.0% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-17.9%
Shrinking sales (-17.9% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
8/8 quarters
Every recent quarter grew earnings vs last year

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-3850.9%
Burning cash (-3850.9%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
2.83
Heavy debt load (2.83)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
no trend
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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