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Taysha Gene Therapies

TSHA
24
Biotechnology · Healthcare
Price
$6.09
-0.02 (-0.33%)
Market Cap
$1.95B
Exchange
NASDAQ
Winston Score
24
Winston is worried
Weak fundamentals across most pillars.
Based on the IPO prospectus (annual filing). This score will refine automatically once the company reports its first quarters.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+749.2% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 37.7M (2021) → 319.7M (2025)

Winston Score History

The full picture

Taysha Gene Therapies is a clinical-stage biotechnology company focused on developing gene therapies for rare neurological diseases. These are serious conditions that affect the brain and nervous system, often caused by a single broken gene. The company's main target patients are people with diseases like Rett syndrome and other rare genetic disorders, and it works closely with academic research centers and patient advocacy groups.

Taysha does not yet sell any approved products, so it earns no meaningful product revenue. Instead, it funds its work through partnerships, licensing deals, and by raising money from investors. The company operates primarily in the United States and is still in early-to-mid clinical trials for its lead programs. Its main competitive edge is its licensed gene therapy platform from the University of Texas Southwestern Medical Center. The biggest risk the company faces is that its therapies must succeed in clinical trials and win regulatory approval before it can generate real revenue — a process that is expensive, uncertain, and can take many years.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-100.0% YoY

YoY Growth Rate

Revenue declining

EPS Growth

-44.1% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$86M/ year

Rising (+31% vs prior year)

884.1% of revenue

49.1x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

17.1%ownership

Declining

Insider ownership declining — could be dilution or selling

Cash Runway

~3 years

$455M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

$455M cash & investments at current burn rate

Heavy R&D investment

Taysha Gene Therapies is putting 884% of revenue into R&D and that number is rising. That's 49.1x the sector average. With 3+ years of cash runway, they have time to let it pay off.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-1130.6%
Losing money on operations — -1130.6%
Return on the money invested
ROCE
-41.7%
Weak — -41.7% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+17.3%
Fast-growing sales (+17.3% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
N/A
Data not available

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-960.1%
Burning cash (-960.1%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.07
Conservative — low debt load (0.07)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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