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Zymeworks

ZYME
27
Biotechnology · Healthcare
Price
$28.67
+2.10 (+7.90%)
Market Cap
$2.11B
Exchange
NASDAQ
Winston Score
27
Winston is worried
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Weak
Cash Flow
Weak
Stability
Good
Valuation
Data not available

Share count rising — dilution

+44.5% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 52.1M (2021) → 75.3M (2025)

Winston Score History

The full picture

Zymeworks is a clinical-stage biotechnology company that develops cancer-fighting drugs. Its main focus is on a class of medicines called antibody-drug conjugates, or ADCs, which are designed to deliver toxic chemicals directly to cancer cells while leaving healthy cells alone. Its lead drug, zanidatamab zovodotin, targets certain breast and other solid tumor cancers, and the company works with major pharmaceutical partners to advance its pipeline.

Zymeworks earns money through a mix of collaboration agreements, licensing deals, and milestone payments from larger pharmaceutical companies — it does not yet sell an approved drug on its own. The company is headquartered in Vancouver, Canada, with significant operations in the United States, and reported roughly $1.8 billion in market capitalization. Its proprietary drug-design technology platform gives it some differentiation in the competitive ADC space, but with a deeply negative operating margin, the biggest risk is burning through cash before any drug reaches commercial approval.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-90.6% YoY

YoY Growth Rate

Revenue declining

EPS Growth

<−1,000% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$137M/ year

Flat (+2% vs prior year)

129.3% of revenue

7.2x the sector average (18%)

Steady R&D investment year-over-year

Insider Activity

7.6%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~10 months

$270.8B cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Short runway — potential dilution ahead through share issuance

Cash watch

Zymeworks has less than a year of cash at its current burn rate. Growth investors should watch for potential share dilution from future fundraising — that directly reduces your ownership.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Profit after running costs
Operating Margin
-919.0%
Losing money on operations — -919.0%
Return on the money invested
ROCE
-0.2%
Weak — -0.2% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
-69.8%
Shrinking sales (-69.8% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
4/8 quarters
Earnings inconsistent quarter-to-quarter

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-209305.4%
Burning cash (-209305.4%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
0.20
Conservative — low debt load (0.20)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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