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Axsome Therapeutics

AXSM
33
Biotechnology · Healthcare
Also trades as: 0HKF.L
Price
$207.77
-0.26 (-0.12%)
Market Cap
$10.69B
Exchange
NASDAQ
Winston Score
33
Winston is serious
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Good
Cash Flow
Weak
Stability
Weak
Valuation
Data not available

Share count rising — dilution

+32.2% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 37.6M (2021) → 49.7M (2025)

Winston Score History

The full picture

Axsome Therapeutics is a pharmaceutical company that develops and sells medicines for brain and nervous system disorders. Its main products include Auvelity, a fast-acting pill for major depressive disorder, and Sunosi, a treatment for excessive daytime sleepiness. The company sells these drugs primarily to patients in the United States through prescriptions written by psychiatrists and other doctors.

Axsome makes money by selling its approved medications directly to pharmacies and specialty distributors, earning revenue each time a prescription is filled. The company operates almost entirely in the US market and is relatively small, with an $11.5 billion market cap. Its high gross margin of 93% reflects the typical economics of branded pharmaceuticals, but it is still spending more than it earns, posting a negative operating margin as it invests heavily in sales and marketing to grow its newer drugs. The key growth driver is continued adoption of Auvelity in a large and underserved depression market, while the main risk is competition from generic antidepressants and potential pricing pressure.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+45.5% YoY

YoY Growth Rate

Strong revenue growth

EPS Growth

-2.1% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$183M/ year

Flat (-2% vs prior year)

28.7% of revenue

1.6x the sector average (18%)

Steady R&D investment year-over-year

Insider Activity

15.4%ownership

Flat

Insider ownership roughly steady over the past year

Cash Runway

~2 years

$320M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

$320M cash & investments at current burn rate

Strong grower

Axsome Therapeutics is growing revenue at 46% year-over-year. The Winston Score penalises unprofitable companies, but revenue at this pace tells a different story — this is a company still in "build mode."

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

Each metric is explained in plain language so you know exactly what you're looking at. Start your free trial now.

Quality

Profit per sale
Gross Margin
93.8%
Premium pricing power — 93.8% gross margin
Profit after running costs
Operating Margin
-22.7%
Losing money on operations — -22.7%
Return on the money invested
ROCE
-69.5%
Weak — -69.5% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+56.9%
Fast-growing sales (+56.9% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
5/8 quarters
Mixed — about half the quarters showed growth

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-9.2%
Burning cash (-9.2%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
2.26
Heavy debt load (2.26)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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