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Codexis

CDXS
35
Biotechnology · Healthcare
Also trades as: 0I0X.L
Price
$1.67
+0.09 (+5.70%)
Market Cap
$179.6M
Exchange
NASDAQ
Winston Score
35
Winston is serious
Below-average fundamentals — multiple weak pillars.
Data as of Aug 23, 2026 · filings through Jun 30, 2026
How the score breaks down
Quality
Mixed
Growth
Good
Cash Flow
Weak
Stability
Weak
Valuation
Data not available

Share count rising — dilution

+35.0% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 64.6M (2021) → 87.1M (2025)

Winston Score History

The full picture

Codexis is a biotechnology company that engineers custom enzymes — tiny biological machines that speed up chemical reactions. Its main customers are pharmaceutical companies that use these enzymes to manufacture drugs more efficiently and cleanly. Codexis also licenses its enzyme technology to the food and industrial sectors, and its CodeEvolver protein engineering platform is a core part of what it sells.

The company earns money through a mix of product sales, technology licensing fees, and research collaboration agreements with large pharma partners. It operates primarily in the United States but serves customers globally. Its main competitive advantage is the CodeEvolver platform, which can design enzymes faster and more precisely than traditional methods, making it difficult for competitors to replicate. The biggest risk Codexis faces is its ongoing unprofitability — it spends significantly more than it earns from operations — meaning it depends on landing new licensing deals and partnerships to keep the business funded.

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-2.7% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+18.8% YoY

YoY Growth Rate

Steady EPS growth

R&D Spend

$52M/ year

Rising (+13% vs prior year)

74.3% of revenue

4.1x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

31.7%ownership

Rising

Insiders increasing their stake — aligned with shareholders

Cash Runway

~16 months

$57M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Adequate runway but may need to raise capital within 2 years

Heavy R&D investment

Codexis is putting 74% of revenue into R&D and that number is rising. That's 4.1x the sector average.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Profit per sale
Gross Margin
76.5%
Premium pricing power — 76.5% gross margin
Profit after running costs
Operating Margin
-75.3%
Losing money on operations — -75.3%
Return on the money invested
ROCE
-23.0%
Weak — -23.0% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales growth
Sales YoY
+35.9%
Fast-growing sales (+35.9% YoY)
Profit growth
EPS YoY
N/A
Data not available
How steady the profit is
EPS Consistency
6/8 quarters
Earnings grew in most of the last 8 quarters

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Cash Flow

Profit that turns into cash
Cash Conversion
N/A
Data not available
Spare cash per sale
FCF Margin
-15.7%
Burning cash (-15.7%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

What it owes vs what it owns
Debt / Equity
2.20
Heavy debt load (2.20)
Covers its interest
Interest Cover
N/A
Data not available

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Valuation

Price vs profit
P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
Cheaper or dearer next year
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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